Expression of Aromatase and survivin and Their Clinicopathologic Significance in Primary Hepatocarcinoma / 中国普外基础与临床杂志

Objective To investigate the expressions of aromatase (Arom) and survivin (Surv) in primary hepatocarcinoma(PHC), and explore their relationships with the clinicopathology of PHC. Methods The specimens from 47 patients with PHC were fixed in 10% formalin and routinely embedded in paraffin. The specimens were continuously sliced into 4 ?m-thick sections. ABC immunohistochemistry was performed to detect the expressions of Arom and Surv with polyclonal antibodies and scored them under high-power microscopy. Results The positive rates and the scores of Arom and Surv in cancer tissues were significantly higher than those of the para-tumor tissues 〔Arom: 40.43% vs 21.28% (P